In Siberia, the prisoner Sergei Kravinoff kills the drug lord Semyon Chorney in a maximum-security prison and flees to meet his partner that is waiting for him in an airplane. While traveling back home, Sergei recalls his saga sixteen years ago, when his father Nikolai Kravinoff travels with his brother Dmitri "Dima" to Tanzania for a hunting trip to prepare them to take over his drug trafficking business in the future. When Nikolai hits a lion, the wounded animal will attack Dima, but Serge protects him. Seriously injured, a girl named Calypso finds him, gives a potion to him and calls assistance, saving his life. She leaves a tarot card with him, and Sergei is miraculously healed. When his father shows the head of the lion as a trophy, Sergei leaves him and goes to the sanctuary that belonged to his mother in Russia. Nowadays, Sergei is a vigilante and urban legend known as Kraven, the Hunter, who hunts criminals. During Dmitri's birthday, Kraven travels to London to celebrate with his brother. But Dmitri is kidnapped and Nikolai refuses to pay the 20 million-dollar-ransom. Now Kraven has to find the man behind the abduction. Aleksei "Rhino" Sytsevich is a powerful competitor of Nikolai that participated in an experiment that gave him the power and strength of a rhinoceros. He hired mercenaries and the Foreigner-who uses hypnotism to defeat his enemies. He has plans to destroy Kraven by using his brother as a bait however Kraven teams up with Calypso (who is now a lawyer in London) to help him in his quest to release Dmitri from his captors.
